Low-fat diet may help reduce fatigue in MS, suggested in a new trial analysis

Dietary changes might alter how body processes fats, ease symptoms

Written by Margarida Maia, PhD | Nov. 10, 2026

A low-fat diet may help reduce fatigue in multiple sclerosis (MS) by altering how the body processes lipids, or fats, and amino acids, which serve as the building blocks of proteins, a small study by U.S. researchers suggests.

These scientists analyzed data from a small clinical trial involving adults with MS that evaluated the effects of starting a low-fat eating plan versus continuing the usual diet. This follow-up analysis specifically focused on potential links between changes in fatigue and metabolism — the full range of chemical reactions whereby the body converts food into energy.

The trial’s participants had experienced a reduction in fatigue after following the low-fat diet. This analysis found decreases in fat mass and low-density lipoprotein (LDL) cholesterol, known as bad cholesterol, among these individuals.

Source: MultipleSclerosisNewstoday